Blar i forfatter "Busche, Tobias"

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    • Bioassay-Guided Fractionation Leads to the Detection of Cholic Acid Generated by the Rare Thalassomonas sp. 

      Pheiffer, Fazlin; Schneider, Yannik Karl Heinz; Hansen, Espen Holst; Andersen, Jeanette Hammer; Isaksson, Johan Mattias; Busche, Tobias; Rückert, Christian; Kalinowski, Jörn; van Zyl, Leonardo; Trindade, Marla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Bacterial symbionts of marine invertebrates are rich sources of novel, pharmaceutically relevant natural products that could become leads in combatting multidrug-resistant pathogens and treating disease. In this study, the bioactive potential of the marine invertebrate symbiont Thalassomonas actiniarum was investigated. Bioactivity screening of the strain revealed Gram-positive specific antibacterial ...

    • Class IV lasso peptides synergistically induce proliferation of cancer cells and sensitize them to doxorubicin 

      Felipe Guerrero-Garzón, Jaime; Madland, Eva; Zehl, Martin; Singh, Madhurendra; Rezaei, Shiva; Aachmann, Finn Lillelund; Courtade, Gaston; Urban, Ernst; Rückert, Christian; Busche, Tobias; Kalinowski, Jörn; Cao, Yan-Ru; Jiang, Yi; Jiang, Cheng-lin; Selivanova, Galina; Zotchev, Sergey (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-10)
      Heterologous expression of a biosynthesis gene cluster from <i>Amycolatopsis</i> sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while having no such effect on the normal cells. Detailed investigation revealed, that pre-treatment of cancer cells with a mixture of felipeptins resulted in ...